AppDomain.CreateDomain

   
 


using System; 

    class MainClass
    {
        public static void Main()
        {
            AppDomainSetup setupInfo = new AppDomainSetup();

            setupInfo.ApplicationBase = @"C:MyRootDirectory";
            setupInfo.ConfigurationFile = "MyApp.config";
            setupInfo.PrivateBinPath = "bin;plugins;external";

            AppDomain newDomain = AppDomain.CreateDomain("My New AppDomain", null, setupInfo);

        }
    }