Configure the AppDomainSetup

   

using System;

class Test
{
    public static void Main()
    {
        AppDomainSetup setupInfo = new AppDomainSetup();

        setupInfo.ApplicationBase = @"C:MyRootDirectory";
        setupInfo.ConfigurationFile = "MyApp.config";
        setupInfo.PrivateBinPath = "bin;plugins;external";

        AppDomain newDomain = 
            AppDomain.CreateDomain("My New AppDomain", null, setupInfo);
    }
}